… , PLKs contain a unique C terminal structure involved in Ser-pSer/pThr binding, called the
Polo box domain (PBD), comprising one or two polo boxes … Their PBDs contain two polo boxes …

… and a C-terminal structure called the polo box domain (PBD) that is … view of the most frequently
studied aspects of PLK functions. … Polo Boxes Come out of the Crypt: A New View of PLK …

… The Polo-like kinases (PLKs) are a family of serine/threonine kinases that play a critical
role … region contains a single Polo-box and a central domain called the “cryptic Polo-box” (CPB). …

… 9 FIGURE 7: PLK functions and localizations in mammalian … In contrast, the PLK4 polo
box and its crypto polo box do not … motif, which is conserved all through evolution (Figure 8). …

… the first to describe and implement a concept of a stem cell as a … a polo-box domain (PBD)
which is a unique feature of the Plk … that our bodies developed evolutionary to silence the alien …

… question of how the centrosome evolved and took its shape was, … thought to lack the cryptic
polo box (CPB) and polo box 3 (PB3) … Thus, while ZYG-1/Plk-4 is recruited in all three species …

… Given that the reductional meiotic program has evolved to … The discovery of polo-like
kinases (PLKs) followed shortly. … PBDs are a tandem set of ~100 amino acid polo boxes …

… (3−5) PLK4, one of the five members of PLKs, also known as … the kinase activity, a “polo-box
(PB)” domain necessary for … ), a rapidly emerging strategy, has evolved as a novel chemical …

… provided a comprehensive view of the … view of the PCM ultrastructure has remained opaque.
Prior to the sub-diffraction-limited-resolution fluorescence imaging era, the accepted view …

… Kinase domains are shown in orange, the polo-box domains in … perspective of PLK4 as a
molecular target for cancer therapy. … PLKs originate from their family ancestral member, the polo/…